Philotheos Bryennios was born in March of 1833 at Constantinople. He was educated at the Theological School in Chalce of the Great Church of Christ and the universities of Leipsic, Berlin, and Munich, and in 1861 became professor of ecclesiastical history, exegesis, and other studies at Chalce. He was appointed master and director at Chalce in 1863, though he soon resigned these two positions. In 1867 he was called to Constantinople to be the head of the “Great School of the Nation” in the Phanar, or Greek quarter of Constantinople. He remained there until 1875 when he was sent by the Most Holy Synod of metropolitans and patriarchs to the Old Catholic conference at Bonn, where he receved a patriarchal letter announcing his appointment as metropolitan of Serrae in Macedonia. In 1877 he was transferred to the metropolitan see of Nicodemia, and in 1880 went to Bucharest on behalf of the Eastern Orthodox Patriarchal and other independent churches to participate in a commission dealing with Greek monastaries that had been plundered in Moldavia and Wallachia. In 1882, at the instance of the Holy Synod of Metropolitans in Constantinople and the patriarch Joachim Il., he wrote a reply (published by the Holy Synod) to the encyclical letter of Pope Leo XIII concerning the Slavic apostles Cyrillus and Methodius. The man was no theological slouch, and despite this list of accomplishments, none of these are the thing for which he is most remembered following his death in 1914 or 1918.